The day went well, and so far, only feeling good after the chemo which ended four hours ago.
The goal with insulin potentiated chemo (IPT) is to first lower the blood sugar until I show signs of hypoglycemia--in my case, on the first day, that number was a glucose of 51. I began to sweat on my brow and have slight palpitations. They then gave 5FU as a push, which running the rest of the Folfari as a drip through my port. It was, well, really cool to be part of the procedure. I felt better after than I began. My vitals were strong at the beginning and end. They then gave me 25 g of albumin to help bring those levels up. I left the clinic feeling energized and hungry. I have eaten 2,000 calories in the intervening four hours, and will eat another 3,000, the desired amount for someone so thinned out by cancer as me, David Vaughn advises me. Something about the procedure really kicked up my appetite. That's extra special good news.
So, lets see in the next days whether there are any side effects. So far, none but feeling better and feeling hungry. Next treatment is on Tuesday, April 20th.
At the clinic, I met more refugees from traditional chemo who were happy to use this IPT chemo which only 10% the dose, and eliminates nearly all the side effects. One woman was proud to show me her hair was growing back, and that the bones in her legs, so debilitated during normal chemo she was in a wheelchair before begining IPT, were now better enough after 13 IPT treatments to allow her to use a walker instead. "Why would you want to do anything else?" she said, saying this is the way standard chemo drugs--which is what we are all taking--should be administered from now on.
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Dear Robert,
ReplyDeleteplease consider the use of red yeast rice in conjunction with what you are doing. See abstract below.
I have also heard of vit C IV used with IPT because insulin may push vit C just like it pushes sugar inside the cells and as you know vit C can act as a prooxidative therapy.
In any case, I have seen an abstract showing that if cancer cells express HMG-COA then inhibiting that pathway inhibits their proliferation by reducing mevalonate. And this is independent of their cholesterol inhibition. And RYR was shown to be be even better than statins at inhibiting cancer, including prostate cancer.
J Nutr Biochem. 2008 Jul;19(7):448-58. Epub 2007 Sep 14.
Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells.
Hong MY, Seeram NP, Zhang Y, Heber D.
Center For Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. myhong@mednet.ucla.edu
Abstract
Chinese red yeast rice (RYR) is a food herb made by fermenting Monascus purpureus Went yeast with white rice. RYR contains a mixture of monacolins, one of which--monacolin K (MK)--is identical to lovastatin (LV). Epidemiological studies show that individuals taking statins have a reduced risk of colon cancer. In the present study, LV decreased cellular proliferation (P<.001) and induced apoptosis (P<.05) in HCT-116 and HT-29 human colon cancer cells. RYR inhibited both tumor cell growths (P<.001) and enhanced apoptosis (P<.05) in HCT-116 cells. Inhibition of proliferation was reversed by mevalonate (MV) in LV-treated cells, since LV is a 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitor. However, RYR with MV did not reverse the observed inhibition of growth. MK-free RYR did not reverse the observed LV-mediated inhibition of cancer cell growth. These observations suggest that other components in RYR, including other monacolins, pigments or the combined matrix effects of multiple constituents, may affect intracellular signaling pathways differently from purified crystallized LV in colon cancer cells. RYR was purified into two fractions: pigment-rich fraction of Chinese red yeast rice (PF-RYR) and monacolin-rich fraction of Chinese red yeast rice (MF-RYR). The effect of MF-RYR was similar to that of LV, while the effect of PF-RYR was similar to the effect of the whole RYR extract on the proliferation, apoptosis and mRNA level of HMGCR and sterol response element binding protein-2. These results suggest that the matrix effects of RYR beyond MK alone may be active in inhibiting colon cancer growth. RYR with or without MK may be a botanical approach to colon cancer chemoprevention worthy of further investigation.